A. KEITH BREWER, Ph.D.
A.. Keith Brewer Science Library,
325 N. Central Ave., Richland Center, WI
53581
THE MECHANISM OF
CARCINOGENESIS
The experimental information presented
in the previous section involving the isotope effect, mass
spectrographic analyses, and fluorescence and
phosphorescence decay, combined with the pH data supplied by
Von Ardenne [23-25], makes it possible to define the
mechanism involved in carcinogenesis. This mechanism is very
different from the accepted one of carcinogens entering the
cell and becoming attached to the DNA. This mechanism will
not explain any of the experimental data outlined briefly
herein.
The proposed mechanism can be outlined
in four steps.
Step 1
The attachment of carcinogenic type
molecules to the membrane surface. This involves two
factors: (a) the presence of carcinogenic-type molecules
primarily of the polycyclic type, and (b) an energized state
of the membrane, which may result from prolonged irritation.
When these molecules are attached to the membrane glucose
can still enter the cell, but oxygen cannot. The cell thus
becomes anaerobic.
Step 2
In the absence of oxygen, the glucose
undergoes fermentation to lactic acid. The cell pH then
drops to 7 and finally down to 6.5.
Step 3
In the acid medium the DNA loses its
positive and negative radical sequence. In addition, the
amino acids entering the cell are changed. As a consequence,
the RNA is changed and the cell completely loses its control
mechanism. Chromosomal aberrations may occur.
Step 4
In the acid medium the various cell
enzymes are completely changed. Von Ardenne has shown that
lysosomal enzymes are changed into very toxic compounds.
These toxins kill the cells in the main body of the tumor
mass. A tumor therefore consists of a thin layer of rapidly
growing cells surrounding the dead mass [3]. The
acid toxins leak out from the tumor mass and poison the
host. They thus give rise to the pains generally associated
with cancer. They can also act as carcinogens.
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